IMMUNE CHECKPOINT INHIBITOR-INDUCED MYASTHENIA GRAVIS: A RARE NEUROLOGIC COMPLICATION OF IMMUNOTHERAPY FOR UROTHELIAL CELL CANCER
نویسندگان
چکیده
منابع مشابه
Myasthenia Gravis: Pathogenesis and Immunotherapy
which typically increases during effort Myasthenia gravis is a chronic autoimmune disease, sub-classified according to the Osserman und Genkins classification (2), and, more recently, that of the MGFA (Myasthenia Gravis Foundation of America) Task-Force (3) (table 1). According to these criteria, ocular MG is characterized by fluctuating unilateral or bilateral ptosis, and, frequently, double v...
متن کاملMyasthenia gravis and pure red cell aplasia: a rare association.
This is a case of a patient who presented with generalised weakness, dysphagia and ptosis. Upon evaluating the patient, she was found to have myasthenia gravis (MG) with anaemia and hypothyroidism. Further evaluation for the cause of anaemia revealed that the patient had pure red cell aplasia (PRCA). CT thorax revealed a thymoma. The patient was given packed cell transfusions, steroids and pyri...
متن کاملImmune complexes in myasthenia gravis.
Low levels of circulating immune complexes were detected in 42% of 50 patients with myasthenia gravis. Although a number of these had other associated autoimmune disorders, 30% of patients with no clinical evidence of other disorders were positive in the assays used. The nature of the antigen or antigens in the complexes is not known. However, no binding of alpha-bungarotoxin (a specific probe ...
متن کاملAcetylcholinesterase inhibitor treatment for myasthenia gravis.
BACKGROUND In myasthenia gravis, antibody-mediated blockade of acetylcholine receptors at the neuromuscular junction abolishes the naturally occurring 'safety factor' of synaptic transmission. Acetylcholinesterase inhibitors provide temporary symptomatic treatment of muscle weakness, but there is controversy about their long-term efficacy, dosage and side effects. OBJECTIVES To evaluate the e...
متن کاملCancer immunotherapy beyond immune checkpoint inhibitors
Malignant cells have the capacity to rapidly grow exponentially and spread in part by suppressing, evading, and exploiting the host immune system. Immunotherapy is a form of oncologic treatment directed towards enhancing the host immune system against cancer. In recent years, manipulation of immune checkpoints or pathways has emerged as an important and effective form of immunotherapy. Agents t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chest
سال: 2020
ISSN: 0012-3692
DOI: 10.1016/j.chest.2020.08.685